How to request a lot-specific COA from a peptide supplier (with template)

Why a lot-specific request matters

A certificate only describes the material that was tested. If the lot number on the certificate does not match the lot number on your vial, the document tells you about a different batch. Many research-peptide storefronts show a sample report on a product page; that is useful for seeing the supplier's format, but it is not the record for your delivery.

The three suppliers this site tracks handle certificates differently. Evolve Peptides says each product has a lot-matched COA retrievable by batch number, and its lookup page says entering the batch number from the label pulls up the certificate and an endotoxin report issued by independent labs. [2] [3] The Peptides-EU FAQ says selected independent certificates from Janoshik Analytical are published, and its Tesamorelin page links purity, endotoxin and sterility reports for the 10 mg vial. [4] [5] Omni Peptides' terms refer to a batch-specific COA library but state that certificates are provided for informational purposes only and that it does not warrant the accuracy, completeness or timeliness of website information. [6] In every case, the request below is how you get the document that matches your lot in writing.

The fields to ask for, and where they come from

Research-grade peptides are not shown to be bound by pharmaceutical good manufacturing practice, but ICH Q7 gives a well-known vocabulary for what a certificate of analysis contains. Section 11.4 says a certificate should give the material name (with grade where appropriate), batch number and date of release; an expiry or retest date where one applies; each test performed with its acceptance limits and numerical results; and a date and signature from authorised quality personnel with the original manufacturer's name, address and telephone number. Where a repacker, agent or broker issues a new certificate, it should name the laboratory that performed the analysis, reference the original manufacturer and original batch certificate, and attach a copy. [1]

Section 17.6 adds that agents, brokers and distributors should give the customer the name of the original manufacturer and the batch numbers supplied. [1] Use that as the basis for asking a reseller who made the material, without assuming the answer.

The raw data worth requesting

A purity percentage is a summary of a chromatogram. Ask for the HPLC chromatogram with its peak integration table, plus the method conditions: column, mobile phases or gradient, detection wavelength and run date. Without the integration table you cannot see whether small peaks were excluded.

For identity, ask for the mass spectrum showing the observed mass next to the theoretical mass for the stated sequence and salt form. If the supplier advertises endotoxin, sterility or heavy-metal testing, as Evolve does on its homepage, ask for those reports for the same lot and their method names. [2] Peptides-EU's FAQ says researchers wanting additional assurance may submit samples to an accredited independent laboratory of their choice, which is the route if raw data is not available. [4]

Copy-ready request template

Subject: Certificate of analysis request, order [order number], lot [lot number from label]

Hello, we received [product name, vial size] under order [order number] on [date]. The label shows lot [lot number]. For our laboratory records, please send the certificate of analysis for this exact lot, including: (1) product name, sequence and salt form; (2) lot number, release date and expiry or retest date; (3) every test performed, with the method, acceptance limit and numerical result; (4) the name of the laboratory that performed each test, the report number and report date; (5) the original manufacturer, if different from your company; (6) the HPLC chromatogram with integration table and the mass spectrum with observed and theoretical mass. If any item is not available, please say which one so we can record it accurately. Thank you, [name, laboratory, date].

Send it through a channel that keeps a record, such as email or a ticket form, and attach a photo of the label so the lot number is not in dispute.

How to judge the reply

Grade the reply against the request, not against how reassuring it sounds. A full packet that matches the lot is the best outcome, but completeness is not proof of authenticity; whether the issuing laboratory is real and accredited is a separate check.

If the supplier declines or goes quiet

Record what you asked, when, through which channel, and the reply word for word. Mark each requested field as present, missing or declined. Do not convert silence into a result, and do not fill gaps from another lot's certificate.

A reasonable rule is one written follow-up after five business days, then close the request as unresolved. From there the options are your laboratory's to decide: send a retained sample to an independent laboratory, quarantine the lot, or choose a supplier whose documentation process fits your requirements. Nothing on this page assesses the material's suitability for any use.