Topic / Certificates of analysis

Peptide certificate of analysis (COA): how to read and check one

Start here for peptide COAs: how to read one, decode its abbreviations, find a supplier's lot certificate and handle a lot number that does not match.

If you are new to peptide certificates, read the COA walkthrough first and keep the abbreviations glossary open beside it. Together they explain what each section of a typical certificate is for and which lines tie it to a specific lot.

Then move from reading to checking. Locate the certificate that belongs to your lot, compare the lot number, quantity and date against the vial label, and record the result. If the lot number does not match, follow the mismatch guide before anyone uses or rejects the material, and keep the correspondence with the supplier.

For detail on individual test results such as HPLC, mass spectrometry, water content or endotoxin, continue to the certificate interpretation guides.

Guides and explainers

Certificates of analysis

Peptide COA abbreviations: HPLC, MS, LAL, KF, TFA and more

A plain-language glossary of the abbreviations found on peptide certificates of analysis, what each test or term shows, and what to check next to it, with links to the deeper guides on this site.

8 min read · Research guide